Publications by authors named "L Borin"

Acquired Aplastic Anemia (AAA) is a rare disease involving primary bone marrow failure with consequent pancytopenia. The addition of the synthetic thrombopoietin-receptor agonist eltrombopag (ELT) to standard immunosuppression for the treatment of AAA has led to improvements in hemopoietic outcomes of AAA. Most of the data on the use of ELT for AAA was based on a maximum of 6 months of therapy.

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Background: When a hematological malignancy is diagnosed, the whole family carries the burden of the disease; parents often try to protect minor children from suffering by avoiding communication about their disease. Since 2009, patients with minors at the Adult Hematology Division at San Gerardo Hospital (Monza) can take part in the "Emanuela Project": children can visit parents and talk with psychologists and hematologists, who explain the disease through simple metaphors.

Materials And Methods: The EMY STUDY aimed to evaluate the impact of illness-related communication on children's behavior, comparing Monza's experience with other Hematology Units, where the communication is delegated to parents or psychological support.

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Historically, the admission of hematological patients in the ICU shortly after the start of a critical illness is associated with better survival rates. Early intensive interventions administered by MET could play a role in the management of hematological critically ill patients, eventually reducing the ICU admission rate. In this retrospective and monocentric study, we evaluate the safety and effectiveness of intensive treatments administered by the MET in a medical ward frame.

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Article Synopsis
  • Myelodysplastic syndromes (MDS) require a specialized treatment approach, and the new Molecular International Prognostic Scoring System (IPSS-M) aims to enhance predictions for patient outcomes compared to the older IPSS-R model.
  • A study of 2,876 patients revealed that IPSS-M significantly improved survival predictions and shifted risk classifications in nearly half of the patients, even those without detectable gene mutations.
  • The findings suggest IPSS-M could better identify patients suitable for hematopoietic stem cell transplantation, although its effectiveness in certain treatment responses remains limited; further research on other influencing factors is necessary.
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