Publications by authors named "L Borgelt"
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- Behavioral and mental health disorders are prevalent among children, adolescents, and young adults, leading to increased use of medications, but there’s limited research on the combinations of these drugs in outpatient settings, particularly in New York Medicaid.
- In a study of over 2.4 million Medicaid enrollees under 21 from 2014, about 5.8% were prescribed BMH medications, with 37.8% of those engaged in polypharmacy, resulting in thousands of distinct drug combinations.
- Although contraindicated drug pairs were relatively rare among those prescribed BMH medications, the study identified risks, particularly related to prolonged QT intervals and serotonin syndrome, emphasizing the need for clinicians to carefully
Article Synopsis
- Infantile hemangioma (IH) is the most common tumor in children, primarily treated with propranolol, which affects blood vessel formation through a specific mechanism involving a protein called SOX18.
- Recent research identified the mevalonate pathway (MVP) as a target of propranolol, highlighting its role in the formation of hemangiomas and confirming this through studies on stem cells from hemangiomas.
- The study suggests that statins, which also target the MVP, could be repurposed to treat IH, revealing a new regulatory axis (SOX18-MVP) that may influence other conditions related to abnormal blood vessel growth.
Background: Alabama's Human Life Protection Act (the Act) signed in 2019 became law in 2022, making provision of abortion a felony offense.
Objective: In 2020, we assessed the accessibility of emergency contraception (EC) pills in Birmingham, Alabama prior to the Act's enactment given the probable increased need for EC access due to abortion criminalization.
Study Design: Pharmacy staff were asked about availability, price, location, and identification requirements to obtain EC.
The RNA-binding protein LIN28 is a regulator of miRNA biogenesis. Inhibitors of LIN28 are highly sought after given the central role that LIN28 plays in tumorigenesis and development of cancer stem cells as well as LIN28's association with poor clinical prognosis. Although LIN28 inhibitors of different scaffolds have been reported, the potential of most LIN28 inhibiting small molecules was not fully explored since very limited structure-activity relationship (SAR) studies have been performed.
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