Publications by authors named "L Borellini"
Article Synopsis
- Dystonia affects about 30% of Parkinson's disease patients and its relationship with deep brain stimulation (DBS) is not well understood.
- A study analyzed data from 80 PD patients who received DBS, focusing on dystonia before and after the procedure in relation to medication status.
- Results showed that patients with off-dystonia improved significantly after DBS, while many with on-dystonia developed it post-surgery, potentially due to higher doses of levodopa prior to the procedure.*
Objective: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) improves motor outcomes in Parkinson's disease (PD) but may have adverse long-term effects on specific cognitive domains. The aim of this study was to investigate the association between total electrical energy (TEED) delivered by DBS and postoperative changes in verbal fluency.
Methods: Seventeen PD patients undergoing bilateral STN-DBS were assessed with the Alternate Verbal Fluency Battery (AVFB), which includes phonemic (PVF), semantic (SVF), and alternate verbal fluency (AVF) tests, before surgery (T0) and after 6 (T1) and 12 months (T2).
Article Synopsis
- Gait disturbances significantly impact the quality of life for Parkinson's disease patients, with current treatments only providing limited benefits.
- Deep brain stimulation (DBS) usually targets symptoms like tremors, but is not very effective for improving gait issues.
- A novel approach called adaptive DBS was tested on one patient, leading to notable improvements in walking and overall symptom management, suggesting it may help optimize stimulation for better gait outcomes.
: High cognitive reserve (CR) has been shown to have beneficial effects on global cognition, cognitive decline, and risk of dementia in Parkinson's disease (PD). We evaluated the influence of CR on the long-term cognitive outcomes of patients with PD who underwent subthalamic nucleus deep brain stimulation (STN-DBS). Twenty-five patients with PD underwent neuropsychological screening using the Montreal Cognitive Assessment (MoCA) at baseline, 1 year, and 5 years after bilateral STN-DBS.
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