Publications by authors named "L Bordone"
Background: Hereditary angioedema (HAE) is a rare, autosomal dominant disorder causing swelling attacks in various parts of the body, resulting in impacts on health-related quality of life (HRQoL). The symptoms of HAE and its impacts on HRQoL have been well-documented in adults; however, relatively little is known about the experiences of adolescents with HAE. The objective of this study was to use qualitative interviews to investigate how adolescents experience HAE symptoms and how HAE impacts their HRQoL.
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- This study investigates the effectiveness and safety of ritlecitinib, a treatment for alopecia areata (AA), over 48 weeks in patients with varying responses by Week 24.
- Results showed that over 85% of patients who had good responses at Week 24 maintained their improvement, while some nonresponders also began to show better results by Week 48.
- The study had a small sample size, but it concludes that ritlecitinib can lead to sustained hair regrowth in many patients with AA.
Article Synopsis
- - Central centrifugal cicatricial alopecia (CCCA) primarily affects Black women and is characterized by scarring that leads to hair loss; conventional treatments focus on inflammation rather than the underlying fibrotic issues.
- - A study was conducted to assess the effects of low-dose oral metformin, an antidiabetic drug with antifibrotic properties, on clinical symptoms and gene expression in CCCA patients unresponsive to standard treatments.
- - Results from 12 participants showed that after at least 6 months of metformin treatment, many experienced symptom improvement and some showed hair regrowth, with gene analysis indicating beneficial changes in pathways related to skin and hair development.