Identification of cavotricuspid isthmus voltage patterns in typical atrial flutter ablation.

Background: Electroanatomical mapping is an essential tool in the ablation of typical AFL.

Objectives: To identify the existence of voltage patterns in the CTI voltage maps and their relevance for typical AFL ablation.

Methods: A voltage map of the CTI was made prior to ablation, identifying the areas of maximum voltage and their location along the CTI, allowing classification into patterns according to their distribution.

Cardiac magnetic resonance outperforms echocardiography to predict subsequent implantable cardioverter defibrillator therapies in ST-segment elevation myocardial infarction patients.

Background: Implantable cardioverter defibrillators (ICD) are effective as a primary prevention measure of ventricular tachyarrhythmias in patients with ST-segment elevation myocardial infarction (STEMI) and depressed left ventricular ejection fraction (LVEF). The implications of using cardiac magnetic resonance (CMR) instead of echocardiography (Echo) to assess LVEF prior to the indication of ICD in this setting are unknown.

Materials And Methods: We evaluated 52 STEMI patients (56.

Transient narrowing of a wide QRS tachycardia. What is the mechanism?

Electrocardiogram showing a regular wide QRS tachycardia with left branch block (LBBB) like in morphology at 200 beats per minute (bpm). During electrophysiology study, it suddenly gets narrow and faster. What is the mechanism of the switch from a broad complex to a narrow complex tachycardia?

Synthesis of C- and H-labelled CHF6001: A new potent PDE4 inhibitor.

An 8-step preparation of C-labelled CHF6001, a potent phosphodiesterase 4 inhibitor in the treatment of respiratory diseases, is described. An overall yield of approximately 9% was obtained starting from copper[ C]cyanide. The synthesis of a stable labelled version of CHF6001 is also reported using the commercially available trideuterated bromomethylcyclopropane as starting material.