Publications by authors named "L Boizeau"
Severe coronavirus disease 2019 (COVID-19) is related to dysregulated immune responses. We aimed to explore the effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants on the immune response by nasopharyngeal transcriptomic in critically-ill patients. This prospective monocentric study included COVID-19 patients requiring intensive care unit (ICU) admission between March 2020 and 2022.
View Article and Find Full Text PDFBackground: Shotgun metagenomics (SMg) sequencing has gained a considerable interest, as it enables the detection of any microorganisms through a single analysis. Due to the limitations of standard microbiological approaches, the microbial documentation of liver abscesses (LA), which is crucial for their medical management, can be difficult. Here we aimed to compare the performance of SMg with standard approaches for the microbiological documentation of LA.
View Article and Find Full Text PDFHepatitis of undetermined origin can be caused by a wide variety of pathogens, sometimes emerging pathogens. We report the discovery, by means of routine shotgun metagenomics, of a new virus belonging to the family Circoviridae, genus Circovirus, in a patient in France who had acute hepatitis of unknown origin.
View Article and Find Full Text PDFArticle Synopsis
- Hepatitis B virus (HBV) is the most common viral infection found in blood donors in France, with a significant majority (98%) of HBV-positive cases from first-time donors between 2000 and 2020.
- Over two decades, there was a notable decrease in both HBV prevalence (2.8-fold) and the risk of transfusion-transmitted HBV infections (13-fold), primarily attributed to the screening processes and the origins of donors.
- The main risk factor for HBV infection was donors from endemic countries (66.5%), with genotype D being the most prevalent among positive cases, while a robust screening strategy ensures high levels of blood safety.
Objective: This study compared two assays aimed at confirming the presence of anti-HCV antibodies (Ab) after a positive screening: Geenius HCV supplemental assay (Bio-Rad, Marne la Coquette, France) and the Inno-LIA HCV score assay (Fujirebio, Les Ulis, France).
Material And Methods: A total of 180 archived samples were investigated including 119 samples collected at different stages of HCV infection in 25 hemodialyzed patients who underwent HCV seroconversion, 14 samples from 4 commercial seroconversion panels, 47 Ab positive/HCV-RNA positive blood donations of which 7 showing an single reactivity in confirmatory assays. Samples were investigated and results were interpreted with the two assays according to the manufacturers' instructions.