Publications by authors named "L Boiardi"
Article Synopsis
- - The study aimed to identify genes that are differently expressed in temporal artery biopsies (TABs) from patients with giant cell arteritis (GCA) showing varied inflammation patterns, specifically transmural inflammation (TMI) and inflammation limited to adventitia (ILA), compared to non-GCA controls.
- - An analysis of 770 immune-related genes revealed that TABs with TMI had significantly more gene expression changes (256 upregulated and 31 downregulated) versus normal TABs, while TABs with ILA mostly resembled normal samples with fewer significant changes.
- - The findings highlighted that TMI TABs exhibit a unique gene expression profile that contributes to understanding GCA's underlying mechanisms, as opposed to TABs with ILA
Objectives: To assess the maintenance of efficacy of one year of tocilizumab (TCZ) monotherapy after its discontinuation in large vessel-GCA (LV-GCA).
Methods: 17 patients with active LV-GCA were previously treated with 3 boluses of intravenous methylprednisone and weekly subcutaneous TCZ in monotherapy for 52 weeks. Patients in relapse-free clinical remission at week 52 discontinued TCZ and entered part two, which was a 26-week observational follow-up period.
Giant cell arteritis (GCA) is an inflammatory disease of large/medium-sized arteries. MiRNAs are small, non-coding RNAs that inhibit gene expression at post-transcriptional level. Several miRNAs have been shown to be dysregulated in temporal artery biopsies (TABs) from GCA patients, but their role is unknown.
View Article and Find Full Text PDFObjectives: To describe the clinical findings, response to therapy and course of patients with transmural eosinophilic infiltration at temporal artery biopsy (TAB).
Methods: The study consisted of a retrospective cohort of 254 consecutive GCA patients with evidence of transmural inflammation at TAB seen at the Santa Maria Nuova Hospital over a 28-year period. The findings of the 22 patients with eosinophilic infiltration (≥ 20 eosinophils/hpf) at TAB were compared with those of 232 patients without.