, the most widely cultivated species of persimmon, has been long used in traditional medicine since its leaves' extracts contain high amounts of flavonoids and terpenoids, endowed with several beneficial effects. However, its anticancer activity towards colorectal cancer (CRC) has not been investigated in depth. The effect of a methanolic extract of leaves, rich in kaempferol and quercetin derivatives, have been evaluated on an E705 CRC cell line, representative of most CRC patients, and on SW480 cells, carrying a KRAS-activating mutation.
View Article and Find Full Text PDFThe spatio-temporal development of a meandering river is controlled by its channel morphodynamics. In regions of rapid channel evolution, understanding the driving factors of meander migration is crucial in forecasting the rate and extent of morphological change. Sediment supply and fluvial discharge are the primary influences on migration rate, however climate oscillations are also integral in indirectly regulating migration rate through their control of regional precipitation, as well as the monsoon season of sub-tropical Asia.
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