Publications by authors named "L Bilodeau"
Background: Lung inflammation is associated with tissue damage in cystic fibrosis (CF). LAU-7b, a novel oral drug candidate, was shown to control inflammation and stabilize CFTR protein in the epithelial membrane during inflammatory stress in preclinical models of CF.
Methods: A double-blind, randomized, placebo-controlled Phase 2 study was conducted to evaluate efficacy and safety of LAU-7b in adults with CF.
Article Synopsis
- Elevated inflammation markers in cystic fibrosis (CF) patients can hinder lung function recovery after exacerbations; the study aimed to see if oral prednisone could help patients who weren’t improving with antibiotics.
- A randomized trial with 173 CF patients tested the effectiveness of prednisone against a placebo after 7 days of antibiotic treatment, measuring recovery of lung function (FEV).
- The results showed no significant difference in lung function recovery between the prednisone group (50% recovery) and the placebo group (39%), suggesting prednisone does not provide additional benefits for these patients.*
Unlabelled: Many people living with diabetes also have nonalcoholic fatty liver disease (NAFLD). Interleukin-6 (IL-6) is involved in both diseases, interacting with both membrane-bound (classical) and circulating (trans-signaling) soluble receptors. We investigated whether secretion of IL-6 trans-signaling coreceptors are altered in NAFLD by diabetes and whether this might associate with the severity of fatty liver disease.
View Article and Find Full Text PDFBackground: Exercise-induced O desaturation contributes to dyspnea and exercise intolerance in various respiratory diseases. This study assessed whether automated O titration was superior to fixed-flow O to improve exertional dyspnea and walking exercise endurance. We also aimed at evaluating possible additive effects of high-flow nasal cannula coupled with automated O titration on these outcomes.
View Article and Find Full Text PDFBackground: Cystic fibrosis (CF) neutrophils fail to eradicate infection despite their massive recruitment into the lung. While studies mostly focus on pathogen clearance by normal density neutrophils in CF, the contribution of low-density neutrophil (LDNs) subpopulations to disease pathogenesis remains unclear.
Methods: LDNs were isolated from whole blood donations of clinically stable adult CF patients and from healthy donors.