High expression of SERPINE1 and CTSL in keratinocytes in pressure injury caused by ischemia-reperfusion injury.

Introduction: Pressure Injury (PI) is a complex disease process which is influenced by multiple factors, among which ischemia-reperfusion (I/R) injury is closely related to the progression of PI. But its biomarkers are still unclearly. Understanding its physiological mechanisms and related molecular biomarkers is a key to developing effective prevention and therapeutic strategies.

Enhanced mechanical properties and in vitro bioactivity of silicon nitride ceramics with SiO, YO, and AlO as sintering aids.

Silicon nitride (Si₃N₄) ceramics exhibit excellent mechanical properties and biocompatibility, making them highly suitable for biomedical applications, particularly in implants. In this study, the mechanical properties and bioactivity of Si₃N₄ ceramics with varying amounts of Y₂O₃-Al₂O₃-SiO₂ sintering aids were investigated. Increasing the sintering additive content from 4 wt% to 8 wt% substantially improved the bulk density of the ceramics, leading to notable enhancements in mechanical properties.

Global trends in the burden of ischemic heart disease based on the global burden of disease study 2021: the role of metabolic risk factors.

Background: Ischemic heart disease (IHD) remains a leading cause of mortality and morbidity globally. This study aims to evaluate the trends in IHD burden across different socioeconomic regions using data from the Global Burden of Disease Study 2021 (GBD 2021) and to understand the impact of the metabolic risk factors on these trends.

Methods: Data from GBD 2021 was analyzed to evaluate the global age-standardized death rates (ASDR) and disability-adjusted life years (ASRDALYs) linked to IHD.

Molecular-Scale Insights into the Heterogeneous Interactions between an -Terphenyl Isocyanide Ligand and Noble Metal Nanoparticles.

The structural and chemical properties of metal nanoparticles are often dictated by their interactions with molecular ligand shells. These interactions are highly material-specific and can vary significantly even among elements within the same group or materials with similar crystal structure. In this study, we surveyed the heterogeneous interactions between an -terphenyl isocyanide ligand and Au and Ag nanoparticles (NPs) at the single-molecule limit.

Nanoscale Manipulation of Single-Molecule Conformational Transition through Vibrational Excitation.

Controlling molecular actions on demand is a critical step toward developing single-molecule functional devices. Such control can be achieved by manipulating the interactions between individual molecules and their nanoscale environment. In this study, we demonstrate the conformational transition of a single pyrrolidine molecule adsorbed on a Cu(100) surface, driven by vibrational excitation through tunneling electrons using scanning tunneling microscopy.