Publications by authors named "L Bernardoni"
Background/objectives: Autoimmune pancreatitis (AIP) is a steroid-responsive inflammatory disease of the pancreas. Few studies investigated pancreatic exocrine function (PEF) in patients suffering from AIP and no definitive data are available on the effect of steroids in PEF recovery. Aim of the study is the evaluation of severe pancreatic insufficiency (sPEI) prevalence in AIP at clinical onset and after steroid treatment.
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- EndoFaster is a tool for real-time diagnosis of Helicobacter pylori (HP) during endoscopic procedures, focusing on ammonium levels in gastric juice.
- A study involved 101 adult patients to assess EndoFaster's accuracy against histology and set a concentration cut-off point (COP) for ammonium.
- Results showed EndoFaster had a diagnostic accuracy of 81.6% when paired with stool antigen tests, and identified an optimal ammonium COP of 67.5 ppm for increased detection accuracy of 88.8% for HP infection.
Article Synopsis
- The study investigates the role of CFTR gene variants in pancreatitis patients, focusing on their functional implications and the effectiveness of CFTR modulator drugs.
- Next-generation sequencing and various tests were conducted to assess CFTR function in vivo, revealing impaired CFTR function in several patients, some of whom had CF-causing mutations.
- The research found that CFTR modulators improved function in specific cases, highlighting the potential for using patient-derived tissues to identify defects and evaluate treatment options.
Background: Endoscopic ultrasound-guided gastroenterostomy (EUS-GE) using lumen apposing metal stent has emerged as a minimally invasive treatment for the management of malignant gastric outlet obstruction (mGOO). We aimed to compare EUS-GE with enteral stenting (ES) for the treatment of mGOO.
Methods: Patients who underwent EUS-GE or ES for mGOO between June 2017 and June 2023 at two Italian centers were retrospectively identified.
A small tumor size may impact the diagnostic performance of endoscopic ultrasound-guided tissue acquisition (EUS-TA) for diagnosing solid pancreatic lesions (SPLs). We aimed to compare the diagnostic yield of EUS-guided fine-needle aspiration (FNA) and biopsy (FNB) in SPLs with a diameter ≤ 15 mm. Consecutive patients who underwent EUS-TA for SPLs ≤ 15 mm between January 2015 and December 2022 in a tertiary referral center were retrospectively evaluated.
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