Publications by authors named "L Bergin"
Aims And Method: We aimed to co-design an intervention optimising the benefits of online arts and culture for mental health in young people for subsequent testing in a trial. Co-design followed the double diamond phases of design, discover, define, develop and deliver.
Results: Navigating the views of all co-designers to produce a testable resource demanded in-depth understanding, and frequent iterations in multiple modalities of the theoretical basis of the intervention, amplification of youth voice and commitment to a common goal.
Objectives: This study aimed to understand young people's perception of the potential utility of arts and culture, focusing on online access, for supporting their mental health.
Design: A qualitative interview study.
Setting: Online.
Article Synopsis
- Cardiomyopathy (CMP) is a hereditary condition, with over 50% of cases lacking identifiable genetic causes through standard testing.
- A study analyzed whole-genome sequencing data from 209 pediatric CMP patients and a larger control group, focusing on both coding and non-coding genetic variants.
- Results revealed that 39% of cases had known pathogenic variants, while 15% had significant regulatory variants affecting the expression of CMP-related genes, highlighting new pathways contributing to early-onset CMP.
Rationale: Dextro-transposition of the great arteries (D-TGA) is a severe congenital heart defect which affects approximately 1 in 4,000 live births. While there are several reports of D-TGA patients with rare variants in individual genes, the majority of D-TGA cases remain genetically elusive. Familial recurrence patterns and the observation that most cases with D-TGA are sporadic suggest a polygenic inheritance for the disorder, yet this remains unexplored.
View Article and Find Full Text PDFAims And Method: To gain a deeper understanding of the use of online culture and its potential benefits to mental health and well-being, sociodemographic characteristics and self-reported data on usage, perceived mental health benefits and health status were collected in an online cross-sectional survey during COVID-19 restrictions in the UK in June-July 2020.
Results: In total, 1056 people completed the survey. A high proportion of participants reported finding online culture helpful for mental health; all but one of the benefits were associated with regular use and some with age.