Dissecting the immune infiltrate of primary luminal B-like breast carcinomas in relation to age.

The impact of aging on the immune landscape of luminal breast cancer (Lum-BC) is poorly characterized. Understanding the age-related dynamics of immune editing in Lum-BC is anticipated to improve the therapeutic benefit of immunotherapy in older patients. To this end, here we applied the 'multiple iterative labeling by antibody neo-deposition' (MILAN) technique, a spatially resolved single-cell multiplex immunohistochemistry method.

International Variability of Barriers to Adherence to Immunosuppressive Medication in Adult Heart Transplant Recipients. A Secondary Data Analysis of the BRIGHT Study.

Non-adherence to immunosuppressive medication among transplant patients is associated with poor clinical outcomes and higher economic costs. Barriers to immunosuppressives are a proximal determinant of non-adherence. So far, international variability of barriers to adherence in transplantation has not been studied.

Caregivers' Perspective on Successful Health Care Transition Outcomes for Adolescents and Young Adults With Special Health Care Needs.

Purpose: There is limited caregiver-reported evidence determining health care transition (HCT) outcomes for their adolescents/young adults with special health care needs (AYA-SHCN). A subcommittee of the International and Interdisciplinary Healthcare Transition Research Consortium aimed to identify multidimensional outcomes of a successful HCT among AYA-SHCN based on parents/caregivers' perspectives.

Methods: After literature review and expert interviews, a three-stage Delphi process identified HCT outcomes based on parents/caregivers' perspectives.

Expanding the Scope of Aluminum Chemistry with Noninnocent Ligands.

ConspectusAluminum is the most abundant metal in the earth's crust at 8%, and it is also widely available domestically in many countries worldwide, which ensures a stable supply chain. To further the applications of aluminum (Al), such as in catalysis and electronic and energy storage materials, there has been significant interest in the synthesis and characterization of new Al coordination compounds that can support electron transfer (ET) and proton transfer (PT) chemistry. This has been achieved using redox and chemically noninnocent ligands (NILs) combined with the highly stable M(III) oxidation state of Al and in some cases the heavier group 13 ions, Ga and In.