Publications by authors named "L Benguigui"

Aim: To determine the impact of the protocol change from slow to fast enteral feeding progression on duration of central venous catheter placement, and the rates of late-onset sepsis and necrotising enterocolitis.

Methods: We compared the evolution of all very low-birth-weight infants admitted on their first postnatal day in neonatal intensive care unit during a 12-month period, before (2021 Cohort) and after (2022 Cohort) implementation of a new feeding protocol. Linear regression model was used to adjust for confounding factors.

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Objective: Adherence to the International Liaison Committee on Resuscitation (ILCOR) algorithm optimizes the initial management of critically ill neonates. In this randomized controlled trial, we assessed the impact of a customizable sequential digital cognitive aid (DCA), adapted from the 2020 ILCOR recommendations, compared with a poster cognitive aid (standard of care [SOC]), on technical and nontechnical performance of junior trainees during a simulated critical neonatal event at birth.

Methods: For this prospective, bicentric video-recorded study, students were recruited on a voluntary basis, and randomized into groups of 3 composed of a pediatric resident and two midwife students.

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Article Synopsis
  • Nitric oxide (NO) is produced by three NO synthase (NOS) enzymes, with endothelial NOS (eNOS) protecting against hypertension and inducible NOS (iNOS) being linked to disease during atherogenesis.
  • In a study using mice, female wild-type (WT) mice showed resistance to thrombosis, but this resistance decreased when iNOS was deleted, while male mice were equally affected regardless of iNOS presence.
  • The research indicates that iNOS-derived NO might help protect female mice from thrombotic issues, suggesting a complex role for iNOS in vascular health despite its association with disease.
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Article Synopsis
  • Inducible nitric oxide synthase (iNOS) influences atherosclerotic lesion formation, with studies comparing ApoE-/- mice with and without iNOS using advanced spectroscopic imaging.
  • Analysis revealed that while iNOS did not alter the tunica media composition, it contributed to larger lesions and higher lipid concentrations in ApoE-/- mice, emphasizing its role in plaque development.
  • Spectroscopic differences suggested that the presence of iNOS leads to changes in protein nitration and structure within the plaques, highlighting the potential of ATR-FTIR imaging for studying atherosclerosis in mouse models.
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