Lung-to-Heart Nano-in-Micro Peptide Promotes Cardiac Recovery in a Pig Model of Chronic Heart Failure.

Background: The lack of disease-modifying drugs is one of the major unmet needs in patients with heart failure (HF). Peptides are highly selective molecules with the potential to act directly on cardiomyocytes. However, a strategy for effective delivery of therapeutics to the heart is lacking.

Proteomic Analysis on Sequential Samples of Cystic Fluid Obtained from Human Brain Tumors.

Cystic formation in human primary brain tumors is a relatively rare event whose incidence varies widely according to the histotype of the tumor. Composition of the cystic fluid has mostly been characterized in samples collected at the time of tumor resection and no indications of the evolution of cystic content are available. We characterized the evolution of the proteome of cystic fluid using a bottom-up proteomic approach on sequential samples obtained from secretory meningioma (SM), cystic schwannoma (CS) and cystic high-grade glioma (CG).

Genetic polymorphisms of blood donors in Algeria through blood groups ABO, RH, and Kell.

Our study included 2465 blood donors unrelated from both sexes, originating from Msila (Algeria), at Msila Blood Transfusion Center (CTS), with the aim of performing an anthropogenetic characterization of the population of M'sila, by studying the three-erythrocyte polymorphic systems ABO, Rhesus, and Kell with their allele frequencies. This allowed us to demonstrate after a multi-varied comparative analysis through principal components analysis (PCA) and hierarchical cluster analysis (HCA) On the one hand, comparing the population of Msila to the different regions of Algeria where we found a genetic proximity with the great south of Algeria going towards the south-east of Algeria. On the other hand, the comparative analysis of Msila's population with other populations in the world based on historical, geographical and cultural profile, by building a tri-hybrid potential parenting model (North Africa, Mediterranean and Middle orient) through the three blood systems, allowed us to identify four potential parents including Egypt and Libya (North Africa) and Saudi Arabia and South Yemen (Middle East), Regarding the third strand of our tri-hybrid model, we did not find any potential parental link with the northern shore of the Mediterranean (southern Europe) despite the historical and geographical link that exists.

Galectin-3: an early predictive biomarker of modulation of airway remodeling in patients with severe asthma treated with omalizumab for 36 months.

Background: Bronchial asthma is a heterogeneous disease characterized by three cardinal features: chronic inflammation, variable airflow obstruction, and airway hyperresponsiveness. Asthma has traditionally been defined using nonspecific clinical and physiologic variables that encompass multiple phenotypes and are treated with nonspecific anti-inflammatory therapies. Based on the modulation of airway remodeling after 12 months of anti-immunoglobulin E (IgE) treatment, we identified two phenotypes (omalizumab responder, OR; and non-omalizumab responder, NOR) and performed morphometric analysis of bronchial biopsy specimens.