Publications by authors named "L Beland"
Autoantibodies contribute to many autoimmune diseases, yet there is no approved therapy to neutralize them selectively. A popular mouse model, experimental autoimmune encephalomyelitis (EAE), could serve to develop such a therapy, provided we can better understand the nature and importance of the autoantibodies involved. Here we report the discovery of autoantibody-secreting extrafollicular plasmablasts in EAE induced with specific myelin oligodendrocyte glycoprotein (MOG) antigens.
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- Hypospadias repair often leads to complications, and while factors like anatomy and surgeon experience are known contributors, the influence of social determinants of health on outcomes is less understood.
- The study aimed to explore how resources and community conditions, assessed through the Childhood Opportunity Index (COI), impact post-operative complications in children who underwent distal hypospadias repair.
- An analysis of 938 patients showed a 14.1% complication rate, but no significant correlations were found between COI, insurance type, race, and complications; however, anatomical factors like glans width and chordee degree were linked to complications.
Si and its oxides have been extensively explored in theoretical research due to their technological importance. Simultaneously describing interatomic interactions within both Si and SiO without the use of ab initio methods is considered challenging, given the charge transfers involved. Herein, this challenge is overcome by developing a unified machine learning interatomic potentials describing the Si/SiO/O system, based on the moment tensor potential (MTP) framework.
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- Micro-Finite Element analysis (μFEA) is commonly used in biomechanical research to predict bone properties but is resource-intensive and time-consuming.
- A new alternative method called Firm and Floppy Boundary LEM (FFB-LEM) is introduced, using LAMMPS software to estimate trabecular bone mechanical properties quickly and accurately.
- FFB-LEM calculations take about 15 minutes compared to 30-50 minutes for traditional FEA methods, with no significant differences in results between the two approaches for both bovine and human bone samples.