Publications by authors named "L Beimers"
Article Synopsis
- - Bone metastasis is a major cause of death in prostate cancer, often linked to the development of castration-resistant forms of the disease that exhibit altered androgen and mTOR signaling pathways.
- - Advanced prostate cancer shows high tumor diversity and cancer stem cell presence, prompting research into therapies specifically targeting these cancer stem cells to slow disease progression.
- - The study utilized patient-derived xenografts to test the mTOR inhibitor Rapalink-1 and found it effectively inhibited tumor growth and altered cancer stem cell properties, indicating a potential targeted treatment approach for advanced prostate cancer.
Manipulation under anaesthesia (MUA) for frozen shoulder (FS) leads to a considerable increase in range of motion and Oxford shoulder score, a significant reduction in pain and around 85% satisfaction.A clearly defined indication for MUA in FS patients cannot be extracted from this review or the available literature. The associating criteria before proceeding to MUA vary widely.
View Article and Find Full Text PDFUrological malignancies, including prostate and bladder carcinoma, represent a major clinical problem due to the frequent occurrence of therapy resistance and the formation of incurable distant metastases. As a result, there is an urgent need for versatile and predictive disease models for the assessment of the individualized drug response in urological malignancies. Compound testing on cultured patient-derived tumor tissues could represent a promising approach.
View Article and Find Full Text PDFAim: To investigate the additional value of physiotherapy after a corticosteroid injection in stage one or two idiopathic frozen shoulders (FSs).
Methods: A two center, randomized controlled trial was done. Patients with a painful early stage idiopathic FS were eligible for inclusion.