Publications by authors named "L Bauchet"
The Ca 3.2 isoform of T-type voltage-gated calcium channels plays a crucial role in regulating the excitability of nociceptive neurons; the endogenous molecules that modulate its activity, however, remain poorly understood. Here, we used serum proteomics and patch-clamp physiology to discover a novel peptide albumin (1-26) that facilitates channel gating by chelating trace metals that tonically inhibit Ca 3.
View Article and Find Full Text PDFBackground: The recent advent of anti-IDH therapies and changes in the WHO classification of gliomas implies estimating the number of patients who could benefit (or not) from anti-IDH treatment. As published data on the current incidence of different subtypes of IDH-mutant gliomas (based on the latest histomolecular WHO classification) are lacking in many countries. The present analysis aims to review the main factors impacting the incidence of gliomas and lower-grade gliomas and to estimate the incidence and prevalence of IDH-mutant gliomas in France.
View Article and Find Full Text PDFArticle Synopsis
- - This study analyzed patient survival rates following the surgical removal of high-grade gliomas (HGG) and identified key factors influencing outcomes using data from a national health database in France.
- - A total of 1,438 patients were examined, revealing a median overall survival (OS) of 1.69 years, with one-year, two-year, and five-year survival rates at 78.5%, 40.3%, and 11.8%, respectively.
- - Factors positively affecting survival included being female, younger age at surgery, completing over six months of chemoradiotherapy with temozolomide, and undergoing redo surgery for recurrence.