Publications by authors named "L Bartolome"
Article Synopsis
- Etrasimod is an oral medication aimed at treating moderately to severely active ulcerative colitis (UC), and this study focused on its impact on patients' health-related quality of life (HRQoL).
- The analysis used data from two Phase 3 clinical trials and assessed HRQoL using various questionnaires at different time points.
- Results showed that patients taking etrasimod experienced significantly greater improvements in HRQoL measures compared to those on a placebo, especially among certain patient groups, indicating the medication's effectiveness.
Partial Water Intrusion and Extrusion in Hydrophobic Nanopores for Thermomechanical Energy Dissipation.
J Phys Chem C Nanomater Interfaces
July 2024
Forced wetting (intrusion) and spontaneous dewetting (extrusion) of hydrophobic/lyophobic nanoporous materials by water/nonwetting liquid are of great importance for a broad span of technological and natural systems such as shock-absorbers, molecular springs, separation, chromatography, ion channels, nanofluidics, and many more. In most of these cases, the process of intrusion-extrusion is not complete due to the stochastic nature of external stimuli under realistic operational conditions. However, understanding of these partial processes is limited, as most of the works are focused on an idealized complete intrusion-extrusion cycle.
View Article and Find Full Text PDFAlthough coveted in applications, few materials expand when subject to compression or contract under decompression, i.e., exhibit negative compressibility.
View Article and Find Full Text PDFArticle Synopsis
- Etrasimod, a daily oral medication for ulcerative colitis, was analyzed for its effectiveness in patients with isolated proctitis, which has often been excluded from such trials.
- In a study involving patients with isolated proctitis and other forms of colitis, those taking etrasimod showed significant improvements in clinical remission and endoscopic results compared to those on placebo.
- The safety profile of etrasimod remained consistent across different patient groups, indicating it is a promising treatment option for both isolated and more extensive colitis conditions.
Exploring the Heat of Water Intrusion into a Metal-Organic Framework by Experiment and Simulation.
ACS Appl Mater Interfaces
January 2024
Wetting of a solid by a liquid is relevant for a broad range of natural and technological processes. This process is complex and involves the generation of heat, which is still poorly understood especially in nanoconfined systems. In this article, scanning transitiometry was used to measure and evaluate the pressure-driven heat of intrusion of water into solid ZIF-8 powder within the temperature range of 278.
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