Publications by authors named "L Barlow-Mosha"

Background: Limited diagnostic capabilities, resources and health worker skills have deterred the advancement of birth defects surveillance systems in most low- and middle-income countries (LMICs). Empowering health workers to identify and diagnose major external birth defects (BDs) is crucial to establishing effective hospital-based BD surveillance. Makerere University-Johns Hopkins University (MU-JHU) Research Collaboration BD Surveillance System consists of three diagnostic levels: (1) surveillance midwives, (2) MU-JHU clinical team, and (3) U.

View Article and Find Full Text PDF
Article Synopsis
  • Dolutegravir-based antiretroviral therapy (ART) is recommended for treating children and adolescents with HIV, but earlier studies raised concerns about its potential link to neural tube defects.
  • A sub-study was conducted within the ODYSSEY trial in Uganda to assess the impact of dolutegravir on folate and vitamin B12 levels, essential for neural tube development, compared to standard care treatments.
  • Results indicated that children on dolutegravir had significantly higher plasma and RBC folate levels at both week 4 and week ≥96 compared to those on standard treatment, suggesting a positive effect of dolutegravir on folate status.
View Article and Find Full Text PDF

The aim of this scoping review was to determine the scope, objectives and methodology of contemporary published research on congenital anomalies (CAs) in sub-Saharan Africa (SSA), to inform activities of the newly established sub-Saharan African Congenital Anomaly Network (sSCAN). MEDLINE was searched for CA-related articles published between January 2016 and June 2021. Articles were classified into four main areas (public health burden, surveillance, prevention, care) and their objectives and methodologies summarized.

View Article and Find Full Text PDF
Article Synopsis
  • The IMPAACT P1104s study assessed neuropsychological outcomes over 96 weeks in children living with HIV aged 5-11 in Sub-Saharan Africa, analyzing the relationship between HIV-related biomarkers and neuropsychological performance.
  • A total of 246 children participated, with significant findings indicating that those on nevirapine displayed poorer cognitive and motor skills compared to those on lopinavir/ritonavir.
  • Key factors impacting neuropsychological outcomes included low birth weight, advanced HIV disease, and elevated viral load, highlighting the importance of antiretroviral therapy choice in managing cognitive health in children with HIV.
View Article and Find Full Text PDF

Sustainable birth defects surveillance systems provide countries with estimates of the prevalence of birth defects to guide prevention, care activities, and evaluate interventions. We used free and open-source software (Open Data Kit) to implement an electronic system to collect data for a hospital-based birth defects surveillance system at four major hospitals in Kampala, Uganda. We describe the establishment, successes, challenges, and lessons learned from using mobile tablets to capture data and photographs.

View Article and Find Full Text PDF