Background: People with disabilities often incur higher costs for healthcare, due to higher needs, greater indirect costs, and the need for services not offered by the public system. Yet, people with disabilities are more likely to experience poverty and so have reduced capacity to pay. Health insurance is an important social protection strategy to meet healthcare needs and avoid catastrophic expenditures for this group.
View Article and Find Full Text PDFUnlabelled: Previous studies have shown that E6 interacts with the E6-associated protein (E6AP) ubiquitin-protein ligase and directs its ubiquitylation activity toward several specific cellular proteins, one of the most important of which is p53. Interestingly, E6AP not only aids in the E6-directed degradation of cellular substrates but also stabilizes the E6 protein by protecting it from proteasome-mediated degradation. However, there is no information available about the ubiquitin ligases that regulate the stability and activity of the human papillomavirus (HPV) E6 oncoprotein in the absence of E6AP.
View Article and Find Full Text PDFIn this special interview series, we profile members of The FEBS Journal Editorial Board to highlight their research focus, perspectives on the journal, and future directions in their scientific fields. Lawrence Banks is the Director-General of the International Centre for Genetic Engineering and Biotechnology (ICGEB) in Trieste, Italy. He has served as an editorial board member of The FEBS Journal since 2013.
View Article and Find Full Text PDFBackground: The influence of aerobic exercise training on cardiovascular adaptations in healthy males versus females is unclear. This systematic review and meta-analysis summarized sex-based differences in cardiac adaptations following aerobic exercise training interventions in healthy adults.
Methods: Five electronic databases were searched from inception to June 2024.