Publications by authors named "L Bankir"
Article Synopsis
- - Urea is a key waste product of protein metabolism in mammals, especially in carnivores and omnivores, where it's excreted in high concentrations to conserve water.
- - The review discusses energy-dependent urea secretion in the proximal tubule of the kidney, identifying the SLC6A18 transporter as responsible for this process, which functions as a glycine/urea antiport.
- - This urea secretion affects the composition of tubular fluid and influences the signaling mechanism at the macula densa, playing a crucial role in regulating glomerular filtration rate (GFR) and urine concentration related to protein intake.
Article Synopsis
- The study looked at how two substances, copeptin and iFGF23, in patients with chronic kidney disease (CKD) might predict bad health outcomes.
- It involved 329 CKD patients and found that higher levels of iFGF23 were linked to worse kidney health and more deaths, while copeptin did not show this link.
- The researchers suggest that checking iFGF23 levels could help doctors better monitor CKD patients, but copeptin levels may not be as helpful.
Background: Evaluation of renal function and of factors associated with its decline are important public health issues. Besides markers of glomerular function [e.g.
View Article and Find Full Text PDFRationale & Objectives: The urine-to-plasma (U/P) ratio of urea is correlated with urine-concentrating capacity and associated with progression of autosomal dominant polycystic kidney disease. As a proposed biomarker of tubular function, we hypothesized that the U/P urea ratio would also be associated with progression of more common forms of chronic kidney disease (CKD).
Study Design: Observational cohort study.
Vaptans or voluntary increased hydration to protect the kidney: how do they compare?
Nephrol Dial Transplant
February 2023
The adverse effects of vasopressin (AVP) in diverse forms of chronic kidney disease have been well described. They depend on the antidiuretic action of AVP mediated by V2 receptors (V2R). Tolvaptan, a selective V2R antagonist, is now largely used for the treatment of patients with autosomal dominant polycystic kidney disease.
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