Publications by authors named "L Bale"
Objective: To determine whether there are differences in healthcare utilization for chronic pain based on location (rural vs urban/suburban) or healthcare system (civilians vs Military Service Members and Veterans [SMVs]) after moderate-severe TBI.
Setting: Eighteen Traumatic Brain Injury Model Systems (TBIMS) Centers.
Participants: A total of 1,741 TBIMS participants 1 to 30 years post-injury reporting chronic pain at their most recent follow-up interview.
Article Synopsis
- Alzheimer's disease (AD) is a worsening brain condition without effective treatments, linked to the buildup of toxic β-amyloid peptides and amyloid plaques.
- Previous studies have connected the insulin-like growth factor (IGF) system to AD, and reduced IGF-I receptor (IGFIR) signaling can alleviate plaque formation and neurodegeneration in mice.
- Research highlighted that deleting PAPP-A, a protein involved in regulating IGF-I, in a mouse model of AD resulted in less plaque, improved brain function, and suggests that targeting PAPP-A could be a new treatment option for AD.
Agenesis of the left hepatic lobe is a rare anomaly described as the absence of liver tissue on the left side of the gallbladder fossa or falciform ligament. Here we report a case of agenesis of the left hepatic lobe identified during educational dissection of an 84-year-old male formalin-fixed cadaver. The gross anatomical characteristics, embryological origin, and clinical relevance of this rare variation are described in this report.
View Article and Find Full Text PDFContext: Proptosis in thyroid eye disease (TED) can result in facial disfigurement and visual dysfunction. Treatment with insulin-like growth factor I receptor (IGF-IR) inhibitors has been shown to be effective in reducing proptosis but with side effects.
Objective: To test the hypothesis that inhibition of IGF-IR indirectly and more selectively with PAPP-A inhibitors attenuates IGF-IR signaling in TED.