Associations of depressive symptoms and cortisol with cognitive performance among memory clinic patients.

Objective: Test the hypothesis that depressive symptoms are associated with cognitive performance and that cortisol levels may explain this association independently of Alzheimer's Disease (AD) biomarker levels.

Design: Longitudinal observational study.

Setting: Memory clinic, Karolinska University Hospital, Stockholm, Sweden.

Presenting Clinical Information on Rare Chromosome 6 Disorders via a Parent-Centered Website: Parental and Professional Views.

The scarcity of clinical information surrounding rare chromosome disorders poses challenges for parents and clinicians. To bridge this gap for chromosome 6 disorders, the Chromosome 6 Project collects detailed genotype and phenotype data, aiming to provide aberration-specific phenotype information to parents via an interactive website. With input from 32 parents and 21 professionals, including medical doctors, cytogeneticists, health psychologists, and communication specialists, we used a three-round Delphi method to determine the type and amount of health-related information to be presented on this website.

Mitochondrial-Mediated Platelet Activation in Polymyalgia Rheumatica.

Objective: Platelet activation is thought to participate in polymyalgia rheumatica (PMR) pathogenesis. Upon platelet activation, mitochondria are expelled into the extracellular space. However, whether extracellular mitochondria are present in patients with PMR and whether they can induce platelet activation is not known.

What is the evidence for dietary modification in the management and prevention of malignant bowel obstruction? A scoping review.

Purpose: Dietary modification is one tool in the multidisciplinary and multi-faceted management of malignant bowel obstruction (MBO). However, the evidence for this has not been systematically explored and no guidelines currently exist. The purpose of this review was to identify the type and breadth of published evidence available to support the use of dietary modification in MBO, and to identify key characteristics of dietary interventions and outcome measures used in evaluating these interventions.

Elevated levels of PAI-1 precede the occurrence of type 2 diabetes mellitus.

Aims: Plasminogen activator inhibitor-1 (PAI-1) is the main inhibitor of the fibrinolytic system and is mainly secreted from adipose tissue. It is associated with cardiovascular disease and has also been considered a possible early risk marker for type 2 diabetes. Here, we present the results of a large prospective study investigating PAI-1 levels in relation to incident type 2 diabetes mellitus.