Tumor classification of adenoid cystic carcinoma: systematic review and meta-analysis.

Adenoid Cystic Carcinoma - ACC is a common neoplasm in major and minor salivary glands with a high risk of metastasis. Thus, the objective of the present study was to perform an analysis to better understand the histological grading systems of the ACC and its influence on tumor prognosis in terms of overall survival, disease-free and metastasis-free. This is a systematic review, with meta-analysis, based on the PRISMA parameters.

Trophoblast-specific Deptor knockdown enhances trophoblast nutrient transport and fetal growth in mice.

Aim: Silencing of DEP-domain containing mTOR-interacting protein (DEPTOR), an endogenous inhibitor of the mammalian target of rapamycin (mTOR) pathway, increases mTOR signaling and System A/L amino acid transport activity in cultured primary human trophoblast cells. However, there is no evidence supporting the regulatory role of DEPTOR signaling in placental function in vivo. We hypothesized that trophoblast-specific Deptor knockdown in mice increases trophoblast mTOR signaling, amino acid transport, and enhances fetal growth.

Effect of Curcumin Pretreatment on the Susceptibility of to Photodynamic Therapy Mediated by Aluminum Phthalocyanine in Nanoemulsion.

Curcumin has antimicrobial activity, and its mechanism of action involves changing histone acetylation. Our group has shown that histone deacetylases (HDACs) inhibitors increase the sensibility of to certain antifungal treatments. Therefore, the aim of this work was to investigate whether curcumin pretreatment increases the effect of photodynamic therapy (PDT) mediated by aluminum phthalocyanine in nanoemulsion (AlPc-NE) against .

Tuberculosis Coalescent Mastoiditis: A Report of Two Rare Cases.

Tuberculous otomastoiditis is a rare disease. Diagnosis generally occurs late when the patient already has irreversible sequelae. Two cases are reported with an unusual presentation of coalescent mastoiditis caused by .

Use of mechanical insufflation-exsufflation devices among intensive care units in Brazil.

Despite its potential benefits, it is unclear how professionals use mechanical insufflation-exsufflation (MI-E) in Brazilian intensive care units (ICUs). This survey aimed to describe MI-E use among health care professionals registered with the Brazilian Association of Intensive Care. Cross-sectional electronic survey of health care professionals (physicians, physiotherapists and nurses) registered with the Brazilian Association of Intensive Care.