Publications by authors named "L B Signorello"
Precision cancer prevention as it is currently envisioned is a targeted, molecular-based approach to intercept carcinogenesis before cancer develops or before it becomes untreatable. Unfortunately, due to systemic biases, current precision cancer prevention interventions might not be effective in all populations, especially in minoritized communities. In addition, not all cancer risk is attributable to genetic or even biological factors, but includes social determinants of health (SDH).
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- African Americans have the highest pancreatic cancer rates in the U.S., and while previous studies linked oral health and microbiome to pancreatic cancer risk, there was a lack of research specifically in this demographic.
- Researchers studied oral microbiome samples from 122 African-American pancreatic cancer patients and 354 controls to explore potential associations with cancer risk.
- No significant differences in microbial diversity or specific oral bacteria were found in the overall group, although some known oral pathogens showed elevated odds ratios among non-smokers.
Although many loci have been associated with height in European ancestry populations, very few have been identified in African ancestry individuals. Furthermore, many of the known loci have yet to be generalized to and fine-mapped within a large-scale African ancestry sample. We performed sex-combined and sex-stratified meta-analyses in up to 52,764 individuals with height and genome-wide genotyping data from the African Ancestry Anthropometry Genetics Consortium (AAAGC).
View Article and Find Full Text PDFPersons of African ancestry (AA) have a twofold higher risk for multiple myeloma (MM) compared with persons of European ancestry (EA). Genome-wide association studies (GWASs) support a genetic contribution to MM etiology in individuals of EA. Little is known about genetic risk factors for MM in individuals of AA.
View Article and Find Full Text PDFBackground: Childhood adversities are prevalent worldwide and might affect adult cardiovascular health. However, in middle-income countries such as Mexico, research on the impact of childhood adversities on cardiovascular disease (CVD) in adulthood is lacking.
Objective: To evaluate the prevalence of adverse childhood experiences (ACEs) and their association with risk factors for CVD in adult Mexican women.