Publications by authors named "L B Siegel"
Choice of Link Functions for Generalized Linear Mixed Models in Meta-Analyses of Proportions.
Res Methods Med Health Sci
January 2025
Two-step approaches for synthesizing proportions in a meta-analysis require first transforming the proportions to a scale where their distribution across studies can be approximated by a normal distribution. Commonly used transformations include the log, logit, arcsine, and Freeman-Tukey double-arcsine transformations. Alternatively, a generalized linear mixed model (GLMM) can be fit directly on the data using the exact binomial likelihood.
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- The study investigates sleep health in children and adolescents with congenital adrenal hyperplasia (CAH) using wrist actigraphy and sleep questionnaires.
- It found that these children had poorer sleep duration, efficiency, and more awakenings compared to healthy peers, particularly related to hydrocortisone medication timing.
- The results indicate that sleep issues are significant for children with CAH, highlighting the need for attention in clinical practice and further research.
Estimating reference intervals from an IPD meta-analysis using quantile regression.
BMC Med Res Methodol
October 2024
Article Synopsis
- Reference intervals are crucial in medical practice, indicating expected measurement ranges for healthy populations, but current methods often rely on aggregate data and parametric assumptions that can be problematic.
- The paper suggests using quantile regression with individual participant data (IPD) in meta-analysis to estimate reference intervals without these assumptions, allowing for more personalized and applicable results for specific patients.
- Simulation studies recommend an optimal bootstrap strategy to estimate the uncertainty of reference intervals, highlighting the method's application in assessing liver stiffness measurements in children.
Norm information in media can predict individuals' norm perceptions and, ultimately, their behavior. Little research has examined how descriptive norm information manifests in media and impacts beliefs in the real world. Previously, using automated content analysis, we measured and examined longitudinal trends in two types of descriptive norm information, individual use depictions and population norms, pertaining to tobacco and e-cigarette use across six media sources from 2014-2017.
View Article and Find Full Text PDFAntibiotics at End of Life: Where Are We Now and Where Are We Going? A Narrative Review.
Am J Hosp Palliat Care
September 2024
Background: Antibiotics are frequently prescribed at the end of life, though the benefits and harms are not well understood.
Methods: We abstracted relevant findings from articles published in English in the past 25 years to answer questions generated by discussion among the authors and with stakeholders in Palliative Care and Infectious Diseases.
Findings: Prescribing practices vary based on individual situation and geographic location.