Publications by authors named "L B Seeff"
Background & Aims: Garcinia cambogia, either alone or with green tea, is commonly promoted for weight loss. Sporadic cases of liver failure from G cambogia have been reported, but its role in liver injury is controversial.
Methods: Among 1418 patients enrolled in the Drug-Induced Liver Injury Network (DILIN) from 2004 to 2018, we identified 22 cases (adjudicated with high confidence) of liver injury from G cambogia either alone (n = 5) or in combination with green tea (n = 16) or Ashwagandha (n = 1).
Article Synopsis
- - The 2020 Nobel Prize in Medicine was awarded to Drs. Harvey Alter, Michael Houghton, and Charles Rice for their groundbreaking work on the hepatitis C virus, leading to lifesaving therapies.
- - The tribute discusses the historical significance of the laureates' discoveries and includes insights from a forum held by the American Association for the Study of Liver Diseases, where the laureates shared advice for emerging scientists.
- - Colleagues and peers in the research community also contribute personal reflections and stories about their experiences working with the Nobel laureates.
Background And Aims: Herbal supplements, and particularly multi-ingredient products, have become increasingly common causes of acute liver injury. Green tea is a frequent component in implicated products, but its role in liver injury is controversial. The aim of this study was to better characterize the clinical features, outcomes, and pathogenesis of green tea-associated liver injury.
View Article and Find Full Text PDFAs part of the United States Pharmacopeia's ongoing review of dietary supplement safety data, a new comprehensive systematic review on green tea extracts (GTE) has been completed. GTEs may contain hepatotoxic solvent residues, pesticide residues, pyrrolizidine alkaloids and elemental impurities, but no evidence of their involvement in GTE-induced liver injury was found during this review. GTE catechin profiles vary significantly with manufacturing processes.
View Article and Find Full Text PDFThe Origins of the Modern-Day Study of Drug Hepatotoxicity: Focus on Hyman J. Zimmerman.
Clin Liver Dis (Hoboken)
February 2020