Publications by authors named "L B Kneipp"
Article Synopsis
- * The researchers discovered calcineurin activity in F. pedrosoi and found it can be inhibited by drugs like FK506 and CsA, which led to cell death and visible changes in the fungal structure.
- * FK506 was the most effective treatment, with a lower required concentration to inhibit growth compared to CsA, and both drugs showed a synergistic effect when combined with itraconazole, highlighting calcineurin as a potential antifungal target.
Article Synopsis
- The study focuses on the effectiveness of copper(II), manganese(II), and silver(I) complexes in combating chromoblastomycosis (CBM), a challenging fungal infection.
- Most tested complexes inhibited conidial viability, with minimum inhibitory concentrations (MICs) between 0.6 to 100 µM, highlighting [Ag(phen)]ClO and [Ag(3,6,9-tdda)(phen)].EtOH as the most potent at 1.2 and 0.6 µM respectively.
- These silver complexes not only decreased biofilm viability but also impeded key fungal activities, suggesting that metal-phen complexes could serve as viable treatment options for CBM.
Brazilian medical mycology considerably expanded in the last decades due to the efforts of several pioneers who started and expanded mycology during the twentieth century. In this manuscript, we highlight some of the contributions of one of these pioneers: Professor Luiz R. Travassos, who started his career in the field of microbiology in the 1960s.
View Article and Find Full Text PDFPatients with chromoblastomycosis (CBM) suffer chronic tissue lesions that are hard to treat. Considering that biofilm is the main growth lifestyle of several pathogens and it is involved with both virulence and resistance to antimicrobial drugs, we have investigated the ability of CBM fungi to produce this complex, organized and multicellular structure. and conidial cells were able to adhere on a polystyrene abiotic substrate, differentiate into hyphae and produce a robust viable biomass containing extracellular matrix.
View Article and Find Full Text PDFis a dematiaceous fungus that causes mainly chromoblastomycosis, but also disseminated infections such as phaeohyphomycosis and mycetoma. These diseases are extremely hard to treat and often refractory to current antifungal therapies. In this work, we have evaluated the effect of 1,10-phenanthroline-5,6-dione (phendione) and its metal-based complexes, [Ag (phendione)]ClO and [Cu(phendione)](ClO).
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