Neurophysiological Markers of Regulation Success in Everyday Life in Depression.

Background: Self-regulation often is disrupted in depression and is characterized by negative affect and inflexible parasympathetic responses. Yet, our understanding of brain mechanisms of self-regulatory processes largely has been limited to laboratory contexts. Measuring individual differences in self-regulatory processes in everyday life - and their neural correlates - could inform our understanding of depression phenotypes and reveal novel intervention targets that impact everyday functioning.

Flap endonuclease 1 repairs DNA-protein cross-links via ADP-ribosylation-dependent mechanisms.

DNA-protein cross-links (DPCs) are among the most detrimental genomic lesions. They are ubiquitously produced by formaldehyde (FA), and failure to repair FA-induced DPCs blocks chromatin-based processes, leading to neurodegeneration and cancer. The type, structure, and repair of FA-induced DPCs remain largely unknown.

A high-resolution in situ X-ray diffraction study of mineral transitions due to post-hydration heating in CM chondrite meteorites.

Abstract: The effects of post-hydration heating over a broad range of temperatures are evident in many Mighei-like carbonaceous (CM) chondrites as a variety of mineral transitions. To better understand these processes and how a CM chondrite's starting composition may have affected them, we experimentally heated two meteorites with different degrees of aqueous alteration, Allan Hills 83100 and Murchison, at 25 °C temperature steps from 200 °C to 950 °C and 300 °C to 750 °C, respectively. During heating, synchrotron in situ X-ray diffraction patterns were collected.

Unveiling the gaps: Assessing LGBTQIA+ inclusivity on emergency medicine residency websites-An analysis of pronoun usage, diversity pages, and LGBTQIA+ sections.

Introduction: Despite progress in promoting diversity, equity, and inclusion (DEI) in medical education, lesbian, gay, bisexual, transgender, queer/questioning, intersex, asexual, and more (LGBTQIA+) individuals remain underrepresented and often face barriers to equitable advancement. Emergency medicine (EM) residency programs are instrumental in creating inclusive environments that attract diverse applicants and support LGBTQIA+ trainees. Since the COVID-19 pandemic's shift to virtual recruitment, residency websites have become vital tools for communicating DEI initiatives.