Publications by authors named "L B Funk"
Background: The efficacy of Glucagon-Like Peptide-1 Receptor Agonists (GLP1RA) for the treatment of obesity has led to considerably increased demand for these medications. GLP1RA use prior to bariatric surgery may represent a novel approach to treating obesity. The objectives of this study were to (1) describe trends in pre-bariatric GLP1RA use, (2) investigate social and clinical factors associated with their use, and (3) evaluate differences in clinical outcomes based on preoperative GLP1RA use.
View Article and Find Full Text PDFIntroduction: Obesity, defined as a body mass index ≥30 kg/m, is a major public health concern in the United States. Preventative approaches are essential, but they are limited by an inability to accurately predict individuals at highest risk of weight gain. Our objective was to develop accurate weight gain prediction models using the National Institutes of Health All of Us dataset.
View Article and Find Full Text PDFArticle Synopsis
- The study focuses on a specific bacterial species that can cause opportunistic infections in humans, making it a useful model for understanding how bacteria can switch from living harmlessly to becoming pathogenic.
- Researchers conducted a comprehensive analysis of the genomic sequences of seven bacterial isolates, discovering a complex structure with several extrachromosomal elements, including a new type of mobile genetic element.
- Key findings include the identification of unique virulence genes, notably the URE gene cluster related to ureolytic activity, highlighting the significance of the flexible genome in influencing the bacterium's ability to cause infections.
The purpose of this article is to assess whether COVID-19 shaped Canadians' preferred settings of dying. We compared data collected using the same survey from two independent but comparable sets of panel respondents, prior to and after the onset of the pandemic. A vignette methodology was used to assess preferences for dying in each of four settings: home, acute/intensive care, palliative care, and long-term residential care.
View Article and Find Full Text PDFArticle Synopsis
- * The study included over 30,000 participants, revealing that 37.4% of them were obese and 20.7% had severe obesity after five years, with notable percentages having gained or lost significant body weight.
- * Findings indicate that factors such as male sex, non-Hispanic Asian ethnicity, and type 2 diabetes are linked to weight loss, while obstructive sleep apnea is associated with weight gain; highlighting the potential of the All of Us dataset in addressing