Publications by authors named "L B E Shields"
Objectives: Proximal median nerve (PMN) neuropathies are caused by lesions proximal to the carpal tunnel, which include the forearm, elbow, upper arm, and brachial plexus. Differentiating between carpal tunnel syndrome and PMN neuropathies is important to guide management and is based on clinical, electrodiagnostic (EDX), and ultrasound (US) findings. This study describes the clinical, EDX, and US features in 62 patients with PMNs.
View Article and Find Full Text PDFHirayama disease (HD) is a rare disorder characterized by insidious asymmetric neurogenic atrophy primarily involving the upper extremities. HD most commonly affects adolescent males and has a favorable prognosis for arrest of progression. Electrodiagnostic (EDX) studies show chronic denervation changes in the distal upper extremity muscles.
View Article and Find Full Text PDFInitial Experience with Lecanemab and Lessons Learned in 71 Patients in a Regional Medical Center.
J Prev Alzheimers Dis
November 2024
Article Synopsis
- The FDA approved lecanemab (Leqembi®) on July 6, 2023, for treating mild cognitive impairment or mild dementia caused by Alzheimer's disease, with early experiences shared from a regional medical center.
- A retrospective study at the Norton Neuroscience Institute Memory Center involved 71 patients, all diagnosed with Alzheimer’s through cerebrospinal fluid biomarkers, most of whom were older, predominantly female, and referred by their primary care providers.
- The study found that 24% of patients experienced amyloid-related imaging abnormalities (ARIA) after treatment, with differences noted between those homozygous and heterozygous for the ApoE4 genotype.
Background: The lateral antebrachial cutaneous nerve (LACN) is the terminal sensory branch of the musculocutaneous nerve and is rarely entrapped or injured. This study describes the electrodiagnostic (EDX) findings and etiologies of LACN neuropathy.
Methods: This is a review of 49 patients with pain and/or paresthesia of the forearm who underwent EDX studies.
Article Synopsis
- The study aimed to compare the effectiveness of intrauterine balloon tamponade and vacuum-induced hemorrhage-control devices in managing postpartum hemorrhage across multiple hospitals using a standardized response protocol.
- Data were collected from 65 hospitals over a 17-month period, involving nearly 123,000 deliveries, with postpartum hemorrhage reported in about 4.8% of cases.
- Results showed that both devices had similar outcomes regarding blood loss, transfusion rates, and device failure, but earlier placement of these devices significantly reduced the need for blood transfusions and the likelihood of device failure.