Publications by authors named "L B Bolton"
Article Synopsis
- Neonatal sepsis is a major cause of death in low- and middle-income countries, worsened by rising antibiotic resistance affecting standard treatments.
- A study analyzed 136 episodes of early onset bloodstream infections (EO-BSI) in neonates from various hospitals in South Africa, revealing a significant prevalence among preterm and low birth weight infants.
- The research found that the overall effectiveness of the recommended antibiotic regimen was only moderate, and neonates with Gram-negative infections had a much higher risk of mortality if their treatment didn't align with the pathogens identified.
Article Synopsis
- * The study involved 23,748 neonates and found a HA-BSI rate of 2.0 per 1000 patient days, with the highest rates in very low birth weight infants and high mortality (31.8%) associated with infections, particularly in preterm and those with Gram-negative/fungal infections.
- * Empiric antibiotic coverage varied by hospital, averaging 66-92%, but concerns were raised about increasing carbapenem resistance, highlighting the need for regular updates to treatment protocols.
Objectives: The functions of eating, drinking, speaking, and breathing demand close coordination of the upper airway musculature which may be challenged by the long-term use of daytime non-invasive ventilation (NIV). This rapid review explores the challenges and practicalities of these interactions in people with neuromuscular disorders.
Methods: A search was performed on PubMed (period 2000-2023) using generic terms to refer to eating, drinking, and speaking related to people with neuromuscular disorders on NIV.
Article Synopsis
- Emerging evidence indicates that immune-modulatory drugs, particularly monoclonal antibodies (mAbs), could be effective for treating depression that doesn't respond to traditional treatments.
- A scoping review analyzed various studies to assess the antidepressant effects of mAbs, finding potential benefits mostly in patients with mild depression related to inflammatory disorders.
- More research is needed to understand the safety and effectiveness of mAbs in patients with severe depression and to better refine their clinical application for this group.
Introduction: Endovenous therapy is the first choice management for symptomatic varicose veins in NICE guidelines, with 56-70 000 procedures performed annually in the UK. Venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), is a known complication of endovenous therapy, occurring at a rate of up to 3.4%.
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