Publications by authors named "L B Bindels"
Alterations in bile acid profile and pathways contribute to hepatic inflammation in cancer cachexia, a syndrome worsening the prognosis of cancer patients. As the gut microbiota impinges on host metabolism through bile acids, the current study aimed to explore the functional contribution of gut microbial dysbiosis to bile acid dysmetabolism and associated disorders in cancer cachexia. Using three mouse models of cancer cachexia (the C26, MC38 and HCT116 models), we evidenced a reduction in the hepatic levels of several secondary bile acids, mainly taurodeoxycholic (TDCA).
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- The study investigates how changes in bile acids contribute to metabolic dysfunction-associated steatohepatitis (MASH), focusing on the role of gut bacteria.
- Mice with MASH on a high-fat diet were compared to their wildtype counterparts to isolate the effects of MASH from diet and environmental factors.
- Findings show that MASH alters bile acid levels through mechanisms unrelated to gut microbiota, particularly highlighting increased enzyme activity in the liver that reduces secondary bile acid levels.
Article Synopsis
- Dietary fibres play a crucial role in preventing chronic diseases and can influence gut health by interacting with gut microbiota, although responses to dietary fibres can vary among individuals.
- There is ongoing debate about how dietary fibres affect microbial diversity, and accurate microbiome assessments are essential for understanding their impact on conditions like obesity and metabolic disorders.
- Higher dietary fibre intake is linked to a lower risk of certain cancers, but further research is needed to explore how specific fibres influence cancer risk and treatment outcomes.
Cancer cachexia is an involuntary loss of body weight, mostly of skeletal muscle. Previous research favors the existence of a microbiota-muscle crosstalk, so the aim of the study was to evaluate the impact of microbiota alterations induced by antibiotics on skeletal muscle proteins expression. Skeletal muscle proteome changes were investigated in control (CT) or C26 cachectic mice (C26) with or without antibiotic treatment (CT-ATB or C26-ATB, = 8 per group).
View Article and Find Full Text PDFSUMMARYThe gut microbiota is a major factor contributing to the regulation of energy homeostasis and has been linked to both excessive body weight and accumulation of fat mass (i.e., overweight, obesity) or body weight loss, weakness, muscle atrophy, and fat depletion (i.
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