Publications by authors named "L Axel"
Thanks to recent developments in cardiovascular magnetic resonance (CMR), cardiac diffusion-weighted magnetic resonance is fast emerging in a range of clinical applications. Cardiac diffusion-weighted imaging (cDWI) and diffusion tensor imaging (cDTI) now enable investigators and clinicians to assess and quantify the tridimensional microstructure of the heart. Free-contrast DWI is uniquely sensitized to the presence and displacement of water molecules within the myocardial tissue, including the intracellular, extracellular, and intravascular spaces.
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- In patients with hypertrophic cardiomyopathy (HCM), the study aimed to evaluate the relationship between apical aneurysm size and common risk factors with the occurrence of deadly arrhythmias and unexplained strokes.
- Among 108 patients studied, 19.4% experienced events like sudden cardiac death or serious arrhythmias, with a significant risk linked to larger aneurysm sizes and the presence of major HCM risk factors.
- Atrial fibrillation was common, and while stroke incidence was low without known causes, overall findings suggest that smaller aneurysms (less than 2 cm) pose a lower risk for severe events over five years.
Cardiac MRI of characteristic motion findings in right bundle branch block.
Int J Cardiovasc Imaging
January 2024
Article Synopsis
- This study investigates specific motion patterns in right bundle branch block (RBBB) during cardiac magnetic resonance imaging (CMR), comparing these findings to normal subjects.
- The researchers identified three key motion patterns: delayed apex-ward motion of the right ventricle (RV) base, "reverse septal flash," and "basal bulge," which were strongly linked to RBBB.
- The combination of these findings had a high specificity for RBBB diagnosis, especially in the 4-chamber view, suggesting that similar features might be observed using other imaging techniques as well.
Modeling of factors affecting late gadolinium enhancement kinetics in MRI of cardiac amyloid.
J Cardiovasc Magn Reson
August 2023
Background: Late gadolinium enhancement (LGE) is a valuable part of cardiac magnetic resonance imaging (CMR). In particular, inversion-recovery imaging of LGE, with nulling of the signal from reference areas of myocardium, can have a distinctive pattern in some patients with cardiac amyloid, including both diffuse (relatively faint) subendocardial LGE and a relatively dark appearance of the blood. However, the underlying reasons for this distinctive appearance have not previously been well investigated.
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- Cardiac radioablation is a new treatment for recurrent ventricular tachycardia, but there's a lack of standardized processes to integrate important electrophysiology data into radiation planning systems.
- A new software tool called HeaRTmap has been developed, which allows the importing and visualization of electrophysiology maps in a 3D format, aiding in cardiac radioablation treatment planning.
- Early results show that HeaRTmap effectively transfers data between systems and accurately defines target volumes for treatment, demonstrating promising integration of mapping data in clinical applications.