Publications by authors named "L Asskour"
Background: Migraine is a complex neurological disorder with significant heterogeneity in its clinical presentation and molecular mechanisms. Calcitonin gene-related peptide (CGRP) has emerged as a key player in migraine pathophysiology, but challenges remain in its utilization as a biomarker. This study aimed to investigate salivary CGRP levels during migraine attacks across the frequency spectrum and explore associations with clinical variables.
View Article and Find Full Text PDFBackground: Several studies have described potential microRNA (miRNA) biomarkers associated with migraine, but studies are scarcely reproducible primarily due to the heterogeneous variability of participants. Increasing evidence shows that disease-related intrinsic factors together with lifestyle (environmental factors), influence epigenetic mechanisms and in turn, diseases. Hence, the main objective of this exploratory study was to find differentially expressed miRNAs (DE miRNA) in peripheral blood mononuclear cells (PBMC) of patients with migraine compared to healthy controls in a well-controlled homogeneous cohort of non-menopausal women.
View Article and Find Full Text PDFArticle Synopsis
- The study seeks to explore salivary CGRP levels in migraine patients, predict response to erenumab treatment from these levels, and assess changes in CGRP post-treatment.
- Higher baseline headache frequency correlates with elevated salivary CGRP levels and depressive symptoms also exacerbate this increase, with a specific cutoff for differentiating migraine patients from healthy controls.
- While higher initial CGRP levels indicate a greater likelihood of significant headache reduction in episodic migraine patients, this correlation does not hold for chronic migraine patients, and treatment with erenumab equalizes CGRP levels across migraine severity, though those with depressive symptoms do not show this change.
Background: CGRP plays a key role in the transmission and modulation of nociceptive signals and is a critical component in the pathogenesis of migraine.
Objective: To assess saliva as a substrate to measure CGRP by comparing interictal levels in patients with episodic migraine and controls; and to evaluate CGRP's temporal profile during migraine attacks.
Methods: This prospective observational pilot study included young women with episodic migraine and healthy controls.