Publications by authors named "L Arvid Larsson"
The growing body of knowledge on the human genome and its variants points towards the significance of genetic factors in oral health and disease. Since the dental curricula have historically prioritized clinically oriented subjects, this focus has resulted in insufficient coverage of genetics. To leverage this knowledge in patient care, dental education must equip students with an understanding of the principles of genetics.
View Article and Find Full Text PDFA major paradigm shift in the diagnosis, management, and survival outcomes of early and advanced non-small cell lung cancer has transpired over the past few decades in thoracic oncology with the incorporation of molecular testing, targeted therapy, immunotherapy, neoadjuvant, and adjuvant approaches. However, transformation in the management and survival outcomes of rare lung tumors is lacking. Given the scarcity of these tumor types, randomized trials are rarely performed, and treatment is extrapolated from case series, tumor-agnostic trials, or cancers with similar histology.
View Article and Find Full Text PDFArticle Synopsis
- Critical illness myopathy (CIM) leads to severe muscle function decline in ICU patients, characterized by muscle mass loss where the reduction in specific force outpaces the muscle mass decrease.
- The hallmark of CIM is marked by a significant reduction in the molecular motor protein myosin, which severely impacts the muscle's ability to generate force.
- An innovative study using cadmium telluride quantum dots revealed that muscle efficiency declines before myosin loss occurs, highlighting early changes in myosin function as potential targets for future CIM treatments.
Importance: Neoadjuvant therapy (NT) is an increasingly used treatment strategy for patients with localized pancreatic ductal adenocarcinoma (PDAC). Little research has been conducted on cancer care delivery during NT, and the standards for optimal delivery of NT have not been defined.
Objective: To develop consensus best practices for delivering NT to patients with localized PDAC.