Publications by authors named "L Aresu"
Article Synopsis
- Hematopoietic neoplasms in dogs are common but their link to pregnancy is rarely documented, presenting numerous challenges in diagnosis and treatment.
- A case study of a pregnant Bernese Mountain Dog revealed advanced hematopoietic cancer and hypercalcemia, leading to the dog's death shortly after diagnosis, before any treatment could be initiated.
- Post-mortem analysis indicated the cancer primarily affected the uterus and placenta but did not involve the fetuses, suggesting that pregnancy may create a unique immune environment that could increase susceptibility to such conditions.
Article Synopsis
- CD37-targeted therapies, like naratuximab emtansine, have shown promise in treating lymphoma, demonstrating strong anti-tumor activity both alone and when combined with rituximab.
- The study investigated 54 lymphoma models, revealing that the drug's effectiveness varied with CD37 expression and discovered mechanisms of resistance related to genetic changes in cancer cells.
- Notable combinations with other drugs (anti-IL6, PI3Kδ inhibitors, and BCL2 inhibitors) improved the drug's efficacy in resistant lymphoma models, suggesting new treatment strategies for tougher cases.
mutations are associated with short survival and poor treatment response in canine diffuse large B-cell lymphoma (cDLBCL). The expression of by RNAscope hybridization and p53 by immunohistochemistry (IHC) was investigated in 37 formalin-fixed paraffin-embedded cDLBCL, to assess their correlation with mutational status and to evaluate their prognostic value. was detected in all samples by RNAscope.
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- Microsatellite instability (MSI) is an important characteristic in cancer, but its role in dog cancers has not been thoroughly studied, prompting this analysis of 10 types of canine tumors using data from 692 samples.
- The study found that 64% of tumors had MSI, with B-cell lymphomas showing the highest levels of MSI, differing from findings in human cancers.
- A new "MSI-burden" score was created, indicating a significant correlation with overall mutation levels, and the results suggest MSI could be a valuable biomarker for prognosis and targeted therapies in canine cancer.
Article Synopsis
- Dogs can have lumps on their spleen that might be harmless (benign) or harmful (malignant), and these could cause bleeding if they break open.
- Surgery to remove the spleen is often needed to find out what kind of lumps they are, but it might not be necessary for harmless ones.
- A study found that testing blood for something called nucleosomes can help tell if the lumps are dangerous, especially in dogs with a serious illness called hemangiosarcoma. More studies are needed to learn more about how this test can help with treatment.