Antitumoral potential of carbamidocyclophanes and carbamidocylindrofridin A isolated from the cyanobacterium Cylindrospermum stagnale BEA 0605B.

Three carbamidocyclophanes, A, F and V, and carbamidocylindrofridin A were isolated from the cultured freshwater cyanobacterium Cylindrospermum stagnale, collected in the Canary Islands. The chemical structures of these compounds were elucidated through NMR, HRMS and ECD spectroscopy. The absolute configuration of carbamidocyclophane A was confirmed using X-ray-diffraction.

Identification of TRPV1 Ion Channels Agonists of Tropaeolum tuberosum in Human Skin Keratinocytes.

commonly known as Mashua, is an herbal remedy used in traditional Andean medicine for the relief of kidney and bladder pain, as well as contusions. This study aimed to evaluate the fractions and isolated compounds from with analgesic activity mediated by the transient receptor potential vanilloid-1 receptor. A bioguided phytochemical analysis based on NMR/MS was performed to identify the compounds of the -heptane fractions from samples of purple tubers of .

Antimicrobial compounds isolated from .

Activity-guided fractionations of black tubers of led to the isolation of 3-[3-(3-pyridinyl)-1,2,4-oxadiazol-5-yl] benzonitrile () and [3,5- (1,1-dimethylethyl)-4-hydroxyphenyl] ethenylidene] -phosphonic acid tetraethyl ester (). Compounds and showed an antibacterial effect against almost all the strains assayed, especially compound showing the same inhibition potential for and as the ampicillin (MIC = 1.5 μM) and a better potential than chloramphenicol which has a MIC of 3.

Expedited Discharge from an Academic Emergency Department: A Pilot Program.

Background: As the numbers of emergency department (ED) visits and inpatient admissions continue to increase, there is growing interest in alternatives to inpatient hospitalization.

Objective: Our aim was to investigate a novel approach to expediting discharges from the ED with multidisciplinary discharge services to prevent an avoidable admission into the hospital.

Methods: This pilot study was conducted at a large urban tertiary-care ED in 2016.