Publications by authors named "L Antoniades"
Naxos disease is a rare autosomal recessive condition combining arrhythmogenic right ventricular cardiomyopathy, woolly hair, and palmoplantar keratoderma. The first identified causative variant was in the gene encoding the desmosomal protein plakoglobin. Naxos disease exhibits fibro-fatty myocardial replacement with immunohistological abnormalities in cardiac protein and signaling pathways, highlighting the role of inflammation and potential anti-inflammatory treatments.
View Article and Find Full Text PDFAims: To study the impact of genotype on the performance of the 2019 risk model for arrhythmogenic right ventricular cardiomyopathy (ARVC).
Methods And Results: The study cohort comprised 554 patients with a definite diagnosis of ARVC and no history of sustained ventricular arrhythmia (VA). During a median follow-up of 6.
Article Synopsis
- Identifies the challenge of determining which patients with hypertrophic cardiomyopathy (HCM) are at risk for sudden cardiac death (SCD) and highlights the 2014 HCM Risk-SCD model by the European Society of Cardiology for predicting 5-year risk assessments.* -
- In a study involving 3,703 patients, only 2% experienced SCD within five years, with the risk model showing effectiveness through a calibration slope of 1.02 and a C-index of 0.70.* -
- The findings support using the HCM Risk-SCD model to allocate implantable cardioverter defibrillator therapy, leading to better outcomes by targeting high-risk patients more efficiently.*
Aims: To determine the incidence and the causes of sudden death (SD) in persons aged 1-35 years old and the diagnostic yield of clinically guided genetic screening in the sudden arrhythmic death syndrome (SADS) victims' families.
Methods And Results: Incidence and causes of SD in the Attica region of Greece in 2002-10 were determined using death certificates and autopsy reports. We evaluated clinically consecutive families of SADS victims and if a clinical diagnosis was established, we proceeded to targeted genetic analysis.
Clinical Significance of Epsilon Waves in Arrhythmogenic Cardiomyopathy.
J Cardiovasc Electrophysiol
November 2015
Introduction: Epsilon waves are hallmark features of arrhythmogenic cardiomyopathy (ACM) but information about their clinical significance is variable. We evaluated epsilon wave prevalence, characteristics, and their clinical significance in an ACM population.
Methods And Results: Eighty-six unselected patients fulfilling the 2010 Task Force criteria were enrolled.