A randomized controlled trial of a moderate-fat, low-energy diet compared with a low fat, low-energy diet for weight loss in overweight adults.

Context: Long-term success in weight loss with dietary treatment has been elusive.

Objective: To evaluate a diet moderate in fat based on the Mediterranean diet compared to a standard low-fat diet for weight loss when both were controlled for energy.

Design: A randomized, prospective 18 month trial in a free-living population.