Publications by authors named "L Antiga"
Article Synopsis
- Liquid-liquid phase separation in the cell nucleus plays a key role in gene regulation, chromatin organization, and DNA repair processes.
- The study utilized lipid-interacting RNA sequencing (LIPRNAseq) and confocal microscopy to explore the interaction of phosphatidylinositol 4,5 bisphosphate (PIP2) with specific RNA, identifying a PIP2-binding RNA motif and its colocalization with long non-coding RNA HANR in the perinucleolar compartment.
- The findings suggest a link between PIP2, lncHANR, and oncogenic super-enhancers, indicating their potential as prognostic markers for cancer and highlighting the importance of understanding lipid metabolism and RNA interactions for future cancer treatment strategies.
Background: Paediatric Inflammatory Crohn's MRE Index (PICMI) is a multi-point index of intestinal inflammation (mucosal and transmural) for children with CD. The present study aims to assess whether PICMI at diagnosis may predict the course of CD and to test the inter-reader agreement.
Methods: CD children with a ≥ 1-year follow-up were retrospectively enrolled.
Article Synopsis
- RNA is essential for forming nuclear compartments, with phosphatidylinositol 4,5-bisphosphate (PIP2) playing a key role in RNA transcription and localization in these compartments.
- The study identified the RNA-dependent PIP2-associated (RDPA) nuclear proteome, revealing that proteins in this group often have intrinsically disordered regions that can bind to PIP2 and possess modification sites.
- Highlighting the relationship between PIP2 and RNA, the research found that the protein BRD4 interacts with PIP2 in an RNA-dependent manner, suggesting that PIP2 is crucial for organizing nuclear processes necessary for gene expression.
Background: Chronic total occlusion (CTO) of the portal vein is one of the main causes of portal hypertension, which may result in life-threatening complications often managed by interventional radiology (IR). The aim of this study is to report the innovative experience with percutaneous revascularization therapy in the management of portal vein CTO in paediatric and adult patients.
Materials And Methods: From January 2020 to December 2023 consecutive paediatric and adult patients with severe portal hypertension resulting from portal vein CTO who underwent attempts at percutaneous recanalization were retrospectively reviewed.
Background & Aims: Glecaprevir/Pibrentasvir (GLE/PIB) has been approved by the European Medicine Agency (EMA) and by the US Food and Drug Administration (US-FDA) for the treatment of children and adolescents from 3 years of age with chronic hepatitis C virus (CHC) infection. The aim of this study was to confirm the real-world effectiveness and safety of GLE/PIB in children and adolescents (3 to < 18 years old) with CHC.
Methods: This prospective, multicentre study involved 11 Italian centres.