Publications by authors named "L Anson-Cartwright"

Purpose: The optimal management of patients with de novo clinical stage IIA/B (CSIIA/B) or relapsed CSIIA/B (Rel-CSIIA/B) seminoma remains debated due to a lack of randomized evidence. Herein, we sought to evaluate outcomes following radiotherapy and chemotherapy in this setting.

Materials And Methods: A prospectively maintained single-institutional database was retrospectively queried for patients diagnosed between 1995-2016 with de novo or Rel-CSIIA/B.

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Background And Objective: Studies in metastatic nonseminomatous germ-cell tumor (NSGCT) suggest that the presence of teratomatous elements in the primary tumor is a risk factor for poor survival. Many guidelines have extrapolated this observation and recommend adjuvant retroperitoneal lymph-node dissection (RPLND) even for clinical stage I (CSI) teratoma confined to the testicle. Our objective was to assess relapse-free survival (RFS), cancer-specific survival (CSS), overall survival (OS) among patients with CSI pure teratoma in comparison to CSI NSGCT.

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Article Synopsis
  • The study investigates the effectiveness of primary retroperitoneal lymph node dissection (pRPLND) as a treatment for testicular germ cell tumors, focusing on lymph node density (LND) as a potential predictor for relapse.
  • A total of 178 patients were reviewed, with 77% showing nodal metastasis, but the study found no significant link between LND and relapse-free survival, despite identifying an optimal LND threshold of 26.75%.
  • The conclusion states that LND is not a reliable prognostic marker for relapse after pRPLND in testicular germ cell tumors, highlighting the unique characteristics of these tumors.
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Objectives: To compare the outcomes and treatment burden of primary retroperitoneal lymph node dissection (pRPLND) alone versus pRPLND + adjuvant chemotherapy (AC) in patients with pathological stage II (PSII) non-seminomatous germ cell tumours (NSGCT).

Patients And Methods: Retrospective review of the Princess Margaret Cancer Center eTestes cancer database identified patients with PSII NSGCT after pRPLND between 1995 and 2020. The primary outcome was relapse-free survival (RFS).

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Article Synopsis
  • Open retroperitoneal lymph node dissection (O-RPLND) is the traditional method for treating retroperitoneal nodal disease in testis cancer, while robotic RPLND (R-RPLND) is gaining popularity for benefits like less blood loss and quicker recovery.
  • A propensity score matching analysis compared the outcomes of O-RPLND and R-RPLND using data from 178 patients over a 32-year period.
  • Results showed that R-RPLND had shorter hospital stays and less estimated blood loss but longer surgery times, with similar relapse rates between the two methods.
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