Publications by authors named "L Ang"
Background: Cardiovascular autonomic neuropathy (CAN) and inflammation predict more severe outcomes in type 1 diabetes (T1D). However, the link between CAN and inflammation in T1D remains unclear. We examined associations between CAN measures and inflammatory biomarkers in individuals with T1D.
View Article and Find Full Text PDFBlood vessels permeate all organs and execute myriad roles in health and disease. Here, we present a protocol to efficiently generate human artery and vein endothelial cells (ECs) from pluripotent stem cells within 3-4 days of differentiation. We delineate how to seed human pluripotent stem cells and sequentially differentiate them into primitive streak, lateral mesoderm, and either artery or vein ECs.
View Article and Find Full Text PDFCongenital hydrocephalus (CH), characterized by cerebral ventriculomegaly (CV), is among the most common and least understood pediatric neurosurgical disorders. We have identified in the largest-assembled CV cohort (>2,697 parent-proband trios) an exome-wide significant enrichment of protein-altering de novo variants (DNVs) in LDB1 (p = 1.11 x 10-15).
View Article and Find Full Text PDFArticle Synopsis
- - The emergence of neuropsychiatric symptoms in middle-aged individuals poses diagnostic challenges, making it tough to distinguish between primary psychiatric disorders and early neurodegenerative diseases, especially when brain imaging shows no clear abnormalities.
- - A case study of a 59-year-old woman showed initial symptoms similar to a mood disorder and behavioral frontotemporal dementia, but autopsy revealed a mix of Lewy body disease and tau-related changes.
- - This case highlights the complexities of diagnosing late-onset neuropsychiatric symptoms, underlines their connection to dementia, and stresses the importance of accurate diagnosis for developing targeted therapies and improving clinical trial participation.
Introduction: The safety of continuing anticoagulation therapy during endoscopic variceal ligation (EVL) remains controversial. We performed a systematic review and meta-analysis to evaluate the safety of anticoagulation therapy in EVL.
Methods: We systematically searched four electronic databases from their inception until 1 June 2024, for studies that evaluated anticoagulation use and risk of rebleeding among patients undergoing EVL.