Publications by authors named "L Andreoletti"

Zika virus (ZIKV) is a major public health problem worldwide. After several reported outbreaks, the current extent of infections caused by this orthoflavivirus in the Sahel remains to be explored. We investigated the prevalence of neutralizing antibodies against ZIKV in the general population, in HIV-infected individuals and in livestock in Chad using a seroneutralization assay that ensures high specificity level.

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Sudden cardiac death (SCD) is a major public health issue worldwide. In the young (< 40 years of age), genetic cardiomyopathies and viral myocarditis, sometimes in combination, are the most frequent, but underestimated, causes of SCD. Molecular autopsy is essential for prevention.

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Major 5'-terminally deleted (5'TD) RNA forms of group-B coxsackievirus (CVB-5'TD) has been associated with myocarditis in both mice and humans. Although it is known that interferon-β (IFN-β) signaling is critical for an efficient innate immune response against CVB-induced myocarditis, the link between CVB-5'TD RNA forms and type I IFN signaling in cardiomyocytes remains to be explored. In a mouse model of CVB3/28-induced myocarditis, major early-emerging forms of CVB-5'TD RNA have been characterized as replicative viral populations that impair IFN-β production in the heart.

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Article Synopsis
  • - SARS-CoV-2 infection can cause both immediate and long-lasting neurological issues, complicating the understanding of the virus's impact on the brain after COVID-19.
  • - Research using brain models and samples shows that while SARS-CoV-2 can infect neural cells, the extent is low, but it can lead to abnormal changes in synapses and electrical activity in the brain.
  • - The study found that treating brain organoids with a specific compound could help restore normal brain activity and reduce the negative effects caused by the virus at synapses, highlighting potential avenues for understanding and treating COVID-19-related brain complications.
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  • A study analyzed 150 nasopharyngeal samples from outpatient cases in northeastern France during the emergence of the SARS-CoV-2 Omicron variant in December 2021, finding that only 3 samples (2%) were Omicron variants while 147 (98%) were delta variants.
  • Phylogenetic analysis suggested that the early Omicron strains might have originated from South Africa or India, and an uncharacterized spike mutation (Y170W) was identified, which was weakly present during this period.
  • The study concluded that a routine whole-genome sequencing approach is crucial for understanding and tracking the genotypic changes of SARS-CoV-2 variants, which could inform public health policies.
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