Publications by authors named "L Amruthalingam"

Background: Vulvar lichen sclerosus (VLS) is a chronic inflammatory skin condition associated with significant impairment of quality of life and potential risk of malignant transformation. However, diagnosis of VLS is often delayed due to its variable clinical presentation and shame-related late consultation. Machine learning (ML)-trained image recognition software could potentially facilitate early diagnosis of VLS.

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Hand eczema (HE) is one of the most frequent dermatoses, known to be both relapsing and remitting. Regular and precise evaluation of the disease severity is key for treatment management. Current scoring systems such as the hand eczema severity index (HECSI) suffer from intra- and inter-observer variance.

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Objectives: Pustular psoriasis (PP) is one of the most severe and chronic skin conditions. Its treatment is difficult, and measurements of its severity are highly dependent on clinicians' experience. Pustules and brown spots are the main efflorescences of the disease and directly correlate with its activity.

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Background: The exact location of skin lesions is key in clinical dermatology. On one hand, it supports differential diagnosis (DD) since most skin conditions have specific predilection sites. On the other hand, location matters for dermatosurgical interventions.

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Article Synopsis
  • The study investigates the potential of tear protein biomarkers to diagnose and predict the severity of ocular graft-versus-host disease (oGVHD) in patients who have undergone allogeneic hematopoietic cell transplantation (AHCT).
  • Researchers analyzed tear samples from 49 patients of varying oGVHD severity grades using advanced mass spectrometry and developed predictive models to classify disease severity.
  • Results showed high accuracy in differentiating disease grades with a specific focus on a 13-marker protein panel that could possibly forecast progression to more severe forms of oGVHD.
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