Can Routine Data be used to Determine the Target Population of Patients with Type 2 Diabetes in Early Benefit Assessments in Germany?

Objectives: Since 2011, early benefit assessment of all new drugs launched in Germany is mandatory. The exact determination of the appropriate target population (i. e.

[Topic Check Medicine: Patient and Consumer Orientation in Topic Collection and Selection for HTA Reports].

Introduction: The involvement of the public in the collection and selection of topics for health technology assessments (HTAs) is an important prerequisite for producing HTA reports on questions actually relevant to patients. In §139b (5) Social Code Book (SGB V), the legislator established the requirements for health insurance members and other interested individuals to propose topics for HTA reports to the Institute for Quality and Efficiency in Health Care (IQWiG).

Objectives: How is the legal remit implemented with regard to the involvement of patients and consumers in topic collection and selection for HTA reports in IQWiG's Topic Check Medicine?

Topic Collection And Selection: Topic proposals for HTA reports can be submitted by any interested individual via a simple submission form on the "ThemenCheck Medizin" website.

Risk of Malignancy in Adenomas Detected During Screening Colonoscopy.

Background & Aims: A higher incidence of proximal interval cancers after colonoscopy has been reported in several follow-up studies. One possible explanation for this might be that proximally located adenomas have greater malignant potential. The aim of the present study was to assess the risk of malignancy in proximal versus distal adenomas in patients included in a large screening colonoscopy database; adenoma shape and the patients' age and sex distribution were also analyzed.

Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, enlarge the parasite's food vacuole and alter drug sensitivities.

Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, are the major determinant of chloroquine resistance in this lethal human malaria parasite. Here, we describe P. falciparum lines subjected to selection by amantadine or blasticidin that carry PfCRT mutations (C101F or L272F), causing the development of enlarged food vacuoles.