NADPH Oxidases: Redox Regulation of Cell Homeostasis & Disease.

The redox signaling network in mammals has garnered enormous interest and taken on major biological significance in recent years as the scope of NADPH oxidases (NOXs) as regulators of physiological signaling and cellular degeneration has grown exponentially. All NOX subtypes have in common the capacity to generate reactive oxygen species (ROS) superoxide anion (O) and/or hydrogen peroxide (HO). A baseline, normal level of ROS formation supports a wide range of processes under physiological conditions.

SURGICAL TREATMENT OF GASTRIC STUMP CANCER: A COHORT STUDY OF 51 PATIENTS.

Background: Gastric stump neoplasia is defined as a neoplasia that arises in the gastric remnant after at least 5 years of interval from the first gastric resection.

Aims: The aim of this study was to analyze 51 patients who underwent total and subtotal gastrectomy and multi-visceral resections in patients with gastric stump cancer.

Methods: The hospital records of 51 patients surgically treated for gastric stump cancer between 1989 and 2019 were reviewed.

Antibody dynamics in dogs submitted to different canine visceral leishmaniasis treatment protocols.

This study evaluated dynamics of antibodies in dogs treated for canine visceral leishmaniasis (CVL). Twenty-one dogs naturally infected by Leishmania spp. were grouped based on the treatment protocol: G1 (n=4) received allopurinol; G2 (n=10) allopurinol with miltefosine; and G3 (n=7) allopurinol, miltefosine and Leish-Tec® vaccine.

Sustainability in Higher Education: Experience report on achieving Sustainable Development Goals.

Objective: Describe the activities aimed at achieving the Sustainable Development Goals (SDGs), implemented by a polytechnic higher education institution, in the northern region of Portugal.

Methods: This is an experience report from a Higher Education Institution, which characterizes the contribution to the SDGs, within the scope of teaching, research, campus and leadership.

Results: In total, 1247 activities were mapped, with a preponderance in the "people" dimension (685 activities), with SDG 3 being the most prominent.

Childbirth dynamics in the riverside region of the Brazilian Amazon from the perspective of geospatialization.

Objective: to analyze the spatial-temporal pattern of childbirths and flow of postpartum women assisted at a regional reference maternity hospital.

Methods: ecological study of 4,081 childbirths, between September 2018 and December 2021, at a public maternity hospital in the Baixo Tocantins region, Pará, Brazil. With data collected from five sources, a geographic database was constructed, and spatial analysis was used with Kernel density interpolator.