Publications by authors named "L Alberghina"
Article Synopsis
- NGF influences neuronal differentiation by promoting mitochondrial fission and fragmentation, enhancing mitochondrial quality and respiration through processes like mitophagy.
- A computer model was developed to visualize and analyze the dynamic interactions of mitochondrial fusion, fission, and mitophagy, successfully simulating these processes along with reactive oxygen species levels and overall mitochondrial quality.
- NGF also triggers significant metabolic changes, affecting glycolysis, the TCA cycle, and the pentose phosphate pathway, which supports energy supply and maintains redox balance for the necessary morphological changes during differentiation.
The Warburg effect is the long-standing riddle of cancer biology. How does aerobic glycolysis, inefficient in producing ATP, confer a growth advantage to cancer cells? A new evaluation of a large set of literature findings covering the Warburg effect and its yeast counterpart, the Crabtree effect, led to an innovative working hypothesis presented here. It holds that enhanced glycolysis partially inactivates oxidative phosphorylation to induce functional rewiring of a set of TCA cycle enzymes to generate new non-canonical metabolic pathways that sustain faster growth rates.
View Article and Find Full Text PDFBackground: Rheumatic heart disease (RHD) is a major cause of cardiovascular disease in developing nations, leading to more than 230,000 deaths annually. Most patients seek medical care only when long-term structural and hemodynamic complications have already occurred. Echocardiographic screenings ensure the early detection of asymptomatic subjects who could benefit from prophylaxis, monitoring and intervention, when appropriate.
View Article and Find Full Text PDFCyclin-dependent kinase 12 (CDK12) overexpression is implicated in breast cancer, but whether it has a primary or only a cooperative tumorigenic role is unclear. Here, we show that transgenic CDK12 overexpression in the mouse mammary gland per se is sufficient to drive the emergence of multiple and multifocal tumors, while, in cooperation with known oncogenes, it promotes earlier tumor onset and metastasis. Integrative transcriptomic, metabolomic and functional data reveal that hyperactivation of the serine-glycine-one-carbon network is a metabolic hallmark inherent to CDK12-induced tumorigenesis.
View Article and Find Full Text PDFArticle Synopsis
- Metabolism is regulated through complex mechanisms that involve both enzyme expression levels and interactions with metabolites, affecting the reaction rates in metabolic pathways.
- High-throughput data from metabolomics and transcriptomics need to be integrated to properly understand these regulatory interactions, as analyzing them separately fails to capture their interdependencies.
- The proposed INTEGRATE computational pipeline combines these data types using metabolic models, helping to distinguish how different regulatory layers affect metabolic fluxes, with practical applications in personalized cancer therapies.