Publications by authors named "L Alaoui"
Improving the selectivity and effectiveness of drugs represents a crucial issue for future therapeutic developments in immuno-oncology. Traditional bulk transcriptomics faces limitations in this context for the early phase of target discovery as resulting gene expression levels represent the average measure from multiple cell populations. Alternatively, single cell RNA sequencing can dive into unique cell populations transcriptome, facilitating the identification of specific targets.
View Article and Find Full Text PDFArticle Synopsis
- The Semmelweis Study in Hungary aims to address the public health challenges of unhealthy aging in the EU by examining the factors that contribute to age-related diseases, particularly vascular cognitive impairment (VCI).
- The pilot study involved 49 participants aged 23 to 87, assessing cognitive performance and vascular health through various advanced imaging techniques and tests.
- The analysis showed a correlation between vascular health indices, age, and cognitive performance, suggesting that a better understanding of this relationship could lead to new insights on healthy aging.
Article Synopsis
- This study in Morocco analyzed the cancer patient journey to identify delays in diagnosis and treatment, highlighting how most patients are diagnosed at advanced stages.
- It involved interviewing 812 recently diagnosed cancer patients across major oncology centers to assess timeframes for various stages of their care.
- Key findings indicated that while the patient interval and treatment times met international guidelines, the diagnosis interval was significantly longer than recommended, which emphasizes the need for improved pathways for cancer care in the region.*
Objective: This study aimed to analyse the learning curve (LC) in laparoscopic rectal cancer resections of 2 millennial surgeons during the implementation of the first laparoscopic rectal cancer surgery programme in low- and middle-income country (LMIC) cancer centre.
Methods: All consecutive patients operated by two millennial surgeons for primary rectal adenocarcinoma between January 2018 and March 2020 were included. The LC was analysed for operative duration and conversion to open surgery using both cumulative sum (CUSUM) and/or variable life-adjusted display (VLAD) charts.
Macrophages play a central role in tissue homeostasis and host defense. However, the properties of human macrophages in non-diseased tissues remain poorly understood. Here, we characterized human tonsil macrophages and identified three subsets with distinct phenotype, transcriptome, life cycle, and function.
View Article and Find Full Text PDF